Mechanical Transport by Molecular Motors:
how do we control traffic in cells?
how do we control traffic in cells?
Defective road condition impact motor traffic. |
We study team work by molecular motors, as controlled by:
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Road condition:
"Single Molecule Investigation of Kinesin-1 Motility Using Engineered Microtubule Defects", M.W. Gramlich, L. Conway, W.H. Liang, J.A. Labastide, S.J. King, J. Xu*, J.L. Ross* (2017)
"Impact of microtubule defect on kinesin-based transport", W. Liang, Q. Li, K M Faysal, S.J. King, A. Gopinathan, J. Xu, Biophys. J., 110, 2229 (2016) PDF
"Interplay between Velocity and Travel Distance of Kinesin-based Transport in the Presence of Tau", Biophys. J., 105, L23 (2013) PDF
Motor number:
"Quantitative Determination of the Probability of Multiple-Motor Transport in Bead-Based Assays", Q. Li, S.J. King, A. Gopinathan, J. Xu, Biophys. J., 111, 2720 (2016) PDF
"Cooperative Protofilament Switching Emerges from Inter-Motor Interference in Multiple-Motor Transport", Sci. Rep., 4, 7255 (2014) Jounal Link
Chemical energy:
"Tuning Multiple Motor Travel Via Single Motor Velocity", Traffic, 13, 1198 (2012) PDF, Supplement
"Single Molecule Investigation of Kinesin-1 Motility Using Engineered Microtubule Defects", M.W. Gramlich, L. Conway, W.H. Liang, J.A. Labastide, S.J. King, J. Xu*, J.L. Ross* (2017)
"Impact of microtubule defect on kinesin-based transport", W. Liang, Q. Li, K M Faysal, S.J. King, A. Gopinathan, J. Xu, Biophys. J., 110, 2229 (2016) PDF
"Interplay between Velocity and Travel Distance of Kinesin-based Transport in the Presence of Tau", Biophys. J., 105, L23 (2013) PDF
Motor number:
"Quantitative Determination of the Probability of Multiple-Motor Transport in Bead-Based Assays", Q. Li, S.J. King, A. Gopinathan, J. Xu, Biophys. J., 111, 2720 (2016) PDF
"Cooperative Protofilament Switching Emerges from Inter-Motor Interference in Multiple-Motor Transport", Sci. Rep., 4, 7255 (2014) Jounal Link
Chemical energy:
"Tuning Multiple Motor Travel Via Single Motor Velocity", Traffic, 13, 1198 (2012) PDF, Supplement
Active Matter, Self-Assembly
"around the world, around the world"
Crowd surfing polymers loop onto themselves.
Crowd surfing polymers loop onto themselves.
"Understanding the role of transport velocity in biomotor-powered microtubule spool assembly",
A.J. Tan, D.E. Chapman, L.S. Hirst, J. Xu, RSC Adv., 6, 79143 (2016) Journal Link PDF
A.J. Tan, D.E. Chapman, L.S. Hirst, J. Xu, RSC Adv., 6, 79143 (2016) Journal Link PDF