Mechanical Transport by Molecular Motors:
how do we control traffic in cells?
how do we control traffic in cells?
Very small cargo moving along very narrow roads. |
Tiny polymers crowd surfing.
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Research focuss: team work by protein machines, as controlled by chemical energy, disease-relevant roadblock (tau), road condition (microtubule structural defect), and mechanical coupling between motors (lipid bilayers).
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Cargo properties:
"Cholesterol in the cargo membrane amplifies tau inhibition of kinesin-1-based transport" PNAS "Cargo diffusion shortens single-kinesin runs" PubMed "A fluid membrane enhances the velocity of cargo transport by small teams of kinesin-1" PubMed Team work: "Tuning ensemble-averaged cargo run length via fractional change in mean kinesin number" PubMed "Quantitative Determination of the Probability of Multiple-Motor Transport in Bead-Based Assays" PubMed "Cooperative Protofilament Switching Emerges from Inter-Motor Interference in Multiple-Motor Transport" PubMed "Tuning Multiple Motor Travel Via Single Motor Velocity" PubMed Road condition: "Native kinesin-1 does not preferentially bind to GTP-rich microtubules in vitro" PubMed "Single Molecule Investigation of Kinesin-1 Motility Using Engineered Microtubule Defects" PubMed "Microtubule defects influence kinesin-based transport in vitro" PubMed "Interplay between Velocity and Travel Distance of Kinesin-based Transport in the Presence of Tau" PubMed |
Qiaochu Michael Li |
Active Matter, Self-Assembly
"around the world, around the world"
Crowd surfing polymers loop onto themselves. |
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"Heterogeneous distribution of kinesin-streptavidin complexes revealed by mass photometry" Soft Matter
"Understanding the role of transport velocity in biomotor-powered microtubule spool assembly" RSC Advances
"Understanding the role of transport velocity in biomotor-powered microtubule spool assembly" RSC Advances