Mechanical Transport by Molecular Motors:
how do we control traffic in cells?
how do we control traffic in cells?
Very small cargo moving along very narrow roads. |
Tiny polymers crowd surfing.
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Research focuss: team work by protein machines, as controlled by chemical energy, disease-relevant roadblock (tau), road condition (microtubule structural defect), and mechanical coupling between motors (lipid bilayers).
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Team work: "Quantitative Determination of the Probability of Multiple-Motor Transport in Bead-Based Assays", Q. Li, S.J. King, A. Gopinathan, J. Xu, Biophys. J., 111, 2720 (2016) PDF
"Cooperative Protofilament Switching Emerges from Inter-Motor Interference in Multiple-Motor Transport", Sci. Rep., 4, 7255 (2014) Jounal Link Road condition: "Impact of microtubule defect on kinesin-based transport", W. Liang, Q. Li, K M Faysal, S.J. King, A. Gopinathan, J. Xu, Biophys. J., 110, 2229 (2016) PDF Roadblock tau: "Interplay between Velocity and Travel Distance of Kinesin-based Transport in the Presence of Tau", Biophys. J., 105, L23 (2013) PDF Chemical energy: "Tuning Multiple Motor Travel Via Single Motor Velocity", Traffic, 13, 1198 (2012) PDF, Supplement |
Qiaochu Michael Li |
Active Matter, Self-Assembly
"around the world, around the world"
Crowd surfing polymers loop onto themselves.
Crowd surfing polymers loop onto themselves.
"Understanding the role of transport velocity in biomotor-powered microtubule spool assembly",
A.J. Tan, D.E. Chapman, L.S. Hirst, J. Xu, RSC Adv., 6, 79143 (2016) Journal Link PDF
A.J. Tan, D.E. Chapman, L.S. Hirst, J. Xu, RSC Adv., 6, 79143 (2016) Journal Link PDF